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中文名: #尼妥珠单抗 #泰欣生
英文名: #Nimotuzumab

本品适用于与放疗联合治疗表皮生长因子受体 #EGFR 表达阳性的III/IV期 #鼻咽癌

用法用量

放射治疗第一天开始前,尼妥珠50mg*2支搭配生理盐水250mg静注。之后每周1次,共8周,患者同时接受标准的放射治疗。

​2008年,我国第一个用于治疗恶性肿瘤的功能性单抗泰欣生(尼妥珠单抗)获准上市,首次打破了国外垄断。EGFR在多种实体瘤中过度表达,如头颈癌、肺癌、结直肠癌中,都存在EGFR过度表达现象。EGFR的过度表达与肿瘤的高侵袭力、高转移性及不良预后高度相关。泰欣生(尼妥珠单抗,Nimotuzumab),是全球第一个以表皮生长因子受体(EGFR)为靶点的单抗,中国第一个治疗恶性肿瘤的人源化单克隆抗体。泰欣生能够竞争性结合EGFR,阻断由EGFR与其介导的下游信号转导通路,从而抑制肿瘤细胞增殖、诱导分化、促进细胞凋亡、抑制肿瘤血管生成、增强放化疗疗效。目前,泰欣生已在中国、美国、德国、加拿大、日本、古巴、印度等20个国家进行多项临床研究,正在开展或已经完成的临床试验约100余项,已入组患者近5000例,包括泰欣生联合放疗、化疗治疗鼻咽癌、头颈部肿瘤、神经胶质瘤、结直肠癌、胰腺癌、食管癌、肝癌、非小细胞肺癌等实体瘤。临床研究证实,患者疾病控制率高,生存获益显著,不良反应轻微,具有很高的临床应用价值。



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中文名: #尼妥珠单抗 #泰欣生
英文名: #Nimotuzumab

本品适用于与放疗联合治疗表皮生长因子受体 #EGFR 表达阳性的III/IV期 #鼻咽癌

用法用量

放射治疗第一天开始前,尼妥珠50mg*2支搭配生理盐水250mg静注。之后每周1次,共8周,患者同时接受标准的放射治疗。

​2008年,我国第一个用于治疗恶性肿瘤的功能性单抗泰欣生(尼妥珠单抗)获准上市,首次打破了国外垄断。EGFR在多种实体瘤中过度表达,如头颈癌、肺癌、结直肠癌中,都存在EGFR过度表达现象。EGFR的过度表达与肿瘤的高侵袭力、高转移性及不良预后高度相关。泰欣生(尼妥珠单抗,Nimotuzumab),是全球第一个以表皮生长因子受体(EGFR)为靶点的单抗,中国第一个治疗恶性肿瘤的人源化单克隆抗体。泰欣生能够竞争性结合EGFR,阻断由EGFR与其介导的下游信号转导通路,从而抑制肿瘤细胞增殖、诱导分化、促进细胞凋亡、抑制肿瘤血管生成、增强放化疗疗效。目前,泰欣生已在中国、美国、德国、加拿大、日本、古巴、印度等20个国家进行多项临床研究,正在开展或已经完成的临床试验约100余项,已入组患者近5000例,包括泰欣生联合放疗、化疗治疗鼻咽癌、头颈部肿瘤、神经胶质瘤、结直肠癌、胰腺癌、食管癌、肝癌、非小细胞肺癌等实体瘤。临床研究证实,患者疾病控制率高,生存获益显著,不良反应轻微,具有很高的临床应用价值。

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Should You Buy Bitcoin?

In general, many financial experts support their clients’ desire to buy cryptocurrency, but they don’t recommend it unless clients express interest. “The biggest concern for us is if someone wants to invest in crypto and the investment they choose doesn’t do well, and then all of a sudden they can’t send their kids to college,” says Ian Harvey, a certified financial planner (CFP) in New York City. “Then it wasn’t worth the risk.” The speculative nature of cryptocurrency leads some planners to recommend it for clients’ “side” investments. “Some call it a Vegas account,” says Scott Hammel, a CFP in Dallas. “Let’s keep this away from our real long-term perspective, make sure it doesn’t become too large a portion of your portfolio.” In a very real sense, Bitcoin is like a single stock, and advisors wouldn’t recommend putting a sizable part of your portfolio into any one company. At most, planners suggest putting no more than 1% to 10% into Bitcoin if you’re passionate about it. “If it was one stock, you would never allocate any significant portion of your portfolio to it,” Hammel says.

For some time, Mr. Durov and a few dozen staffers had no fixed headquarters, but rather traveled the world, setting up shop in one city after another, he told the Journal in 2016. The company now has its operational base in Dubai, though it says it doesn’t keep servers there.Mr. Durov maintains a yearslong friendship from his VK days with actor and tech investor Jared Leto, with whom he shares an ascetic lifestyle that eschews meat and alcohol.

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